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Publications

2016

  • Beitzen-Heineke A, Bouzani M, Schmitt AL, Kurzai O, Hünniger K, Einsele H, Loeffler J (2016) Human Invariant Natural Killer T cells possess immune-modulating functions during Aspergillus infection.
    Med Mycol 54(2):169-176.
  • Blaurock N, Schmerler D, Hünniger K, Kurzai O, Ludewig K, Baier M, Brunkhorst FM, Imhof D, Kiehntopf M (2016) C-Terminal Alpha-1 Antitrypsin Peptide: A New Sepsis Biomarker with Immunomodulatory Function.
    Mediators Inflamm 2016:6129437.
  • Böhringer M, Pohlers S, Schulze S, Albrecht-Eckardt D, Piegsa J, Weber M, Martin R, Hünniger K, Linde J, Guthke R, Kurzai O (2016) Candida albicans infection leads to barrier breakdown and a MAPK/NF-?B mediated stress response in the intestinal epithelial cell line C2BBe1.
    Cellular Microbiology 18(7):889-904.
  • Brandes S, Dietrich S, Hünniger K, Kurzai O, Figge MT (2016) Migration and Interaction Tracking for Quantitative Analysis of Phagocyte-Pathogen Confrontation Assays.
    Medical Image Analysis 36:172-183.
  • Czakai K, Leonhardt I, Dix A, Bonin M, Linde J, Einsele H, Kurzai O, Löffler J (2016) Krüppel-like Factor 4 modulates interleukin-6 release in human dendritic cells after in vitro stimulation with Aspergillus fumigatus and Candida albicans
    Sci Rep 6:27990.
  • Fliesser M, Wallstein M, Kurzai O, Einsele H, Löffler J (2016) Hypoxia attenuates anti-Aspergillus fumigatus immune responses initiated by human dendritic cells.
    Mycoses 59(8):503-508.
  • Hellwig D, Voigt J, Bouzani M, Löffler J, Albrecht-Eckardt D, Weber M, Brunke S, Martin R, Kurzai O, Hünniger K (2016) Candida albicans induces metabolic reprogramming in human NK cells and responds to perforin with a Zinc depletion response.
    Front Microbiol 7:750.
  • Hube B, Kurzai O (2016) Text book chapter in: Clinical Mycology at Oxford University Press. Chapter: Candida. In: Clinical Mycology Oxford University Press.
  • Janhsen WK, Arnold C, Hentschel J, Lehmann T, Pfister W, Baier M, Böer K, Hünniger K, Kurzai O, Hipler UC, Mainz JG (2016) Colonization of CF patients' upper airways with S. aureus contributes more decisively to upper airway inflammation than P. aeruginosa.
    Med Microbiol Immunol 205(5):485-500.
  • Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krüger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR (2016) Candidalysin is a fungal peptide toxin critical for mucosal infection.
    Nature 532(7597):64-68.
  • Pohlers S, Martin R, Krüger T, Hellwig D, Hänel F, Kniemeyer O, Saluz HP, Van Dijck, Ernst JF, Brakhage A, Mühlschlegel FA, Kurzai O (2016) Lipid signaling via Pkh1/2 regulates fungal CO2 sensing through the kinase Sch9.
    mBio Accepted.
  • Polke M, Sprenger M, Scherlach K, Albán-Proaño MC, Martin R, Hertweck C, Hube B, Jacobsen ID (2016) A functional link between hyphal maintenance and quorum sensing in Candida albicans.
    Mol Microbiol Epub ahead of print.
  • Scherag A, Schöneweck F, Kesselmeier M, Taudien S, Platzer M, Felder M, Sponholz C, Rautanen A, Hill AV, Hinds CJ, Hossain H, Suttorp N, Kurzai O, Slevogt H, Giamarellos-Bourboulis EJ, Armaganidis A, Trips E, Scholz M, Brunkhorst FM (2016) Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28Day Mortality.
    EBioMedicine 12:239-246.
  • Taudien S, Lausser L, Giamarellos-Bourboulis EJ, Sponholz C, Schöneweck F, Felder M, Schirra LR, Schmid F, Gogos C, Groth S, Petersen BS, Franke A, Lieb W, Huse K, Zipfel PF, Kurzai O, Moepps B, Gierschik P, Bauer M, Scherag A, Kestler HA, Platzer M (2016) Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive.
    EBioMedicine 12:227-238.

2015

  • Fliesser M, Morton CO, Bonin M, Ebel F, Hünniger K, Kurzai O, Einsele H, Löffler J (2015) Hypoxia-inducible factor 1alpha modulates metabolic activity and cytokine release in anti-Aspergillus fumigatus immune responses initiated by human dendritic cells.
    Int J Med Microbiol 305(8):865-73.
  • Essig F, Hünniger K, Dietrich S, Figge MT, Kurzai O (2015) Human neutrophils dump Candida glabrata after intracellular killing.
    Fungal Genetics and Biology 84:37-40
  • Huyke J, Martin R, Walther G, Weber M, Kaerger K, Bougnoux ME, Elias J, Kurzai O (2015) Candida albicans bloodstream isolates in a German university hospital are genetically heterogenous and susceptible to commonly used antifungals.
    Int J Med Microbiol 305(7):742-747
  • Lehnert T, Timme S, Pollmächer J, Hünniger K, Kurzai O, Figge MT (2015) Bottom-up modeling approach for the quantitative estimation of parameters in pathogen-host interactions.
    Frontiers in Microbiology 6:608,
  • Duggan S, Essig F, Hünniger K, Mokhtari Z, Bauer L, Lehnert T, Brandes S, Häder A, Jacobsen ID, Martin R, Figge MT, Kurzai O (2015) Neutrophil activation by Candida glabrata but not Candida albicans promotes fungal uptake by monocytes.
    Cell Microbiol 17(9):1259-1276.
  • Dix A, Hünniger K, Weber M, Guthke R, Kurzai O, Linde J (2015) Biomarker-based classification of bacterial and fungal whole-blood infections in a genome-wide expression study.
    Front Microbiol 6:171
  • Duggan S, Leonhardt I, Hünniger K, Kurzai O (2015) Host response to Candida albicans bloodstream infection and sepsis.
    Virulence 6(4):316-26
  • Leonhardt I, Spielberg S, Weber M, Albrecht-Eckardt D, Bläss M, Claus R, Barz D, Scherlach K, Hertweck C, Löffler J, Hünniger K, Kurzai O (2015) The fungal quorum-sensing molecule farnesol activates innate immune cells but suppresses cellular adaptive immunity
    MBio 6(2):e00143.
  • Brandes S, Mokhtari Z, Essig F, Hünniger K, Kurzai O, Figge MT (2015) Automated segmentation and tracking of non-rigid objects in time-lapse microscopy videos of polymorphonuclear neutrophils
    Med Image Anal 20(1):34-51
  • Linde J, Duggan S, Weber M, Horn F, Sieber P, Hellwig D, Riege K, Marz M, Martin R, Guthke R, Kurzai O (2015) Defining the transcriptomic landscape of Candida glabrata by RNA-Seq
    Nucleic Acids Res, 43(3):1392-406.
  • Hünniger K, Bieber K, Martin R, Lehnert T, Figge MT, Löffler J, Guo RF, Riedemann NC, Kurzai O (2015) A second stimulus required for enhanced antifungal activity of human neutrophils in blood is provided by anaphylatoxin c5a.
    J Immunol 194(3):1199-210):1199-210

2014

  • Wartenberg A, Linde J, Martin R, Schreiner M, Horn F, Jacobsen ID, Jenull S, Wolf T, Kuchler K, Guthke R, Kurzai O, Forche A, d'Enfert C, Brunke S, Hube B (2014) Microevolution of Candida albicans in macrophages restores filamentation in a nonfilamentous mutant
    PLoS Genet e1004824
  • Ekaney M, Otto G, Sossdorf M, Sponholz C, Boehringer M, Loesche W, Rittirsch D, Wilharm A, Kurzai O, Bauer M, Claus R (2014) Impact of plasma histones in human sepsis and their contribution to cellular injury and inflammation
    Crit Care 18(5):543
  • Lother J, Breitschopf T, Krappmann S, Morton CO, Bouzani M, Kurzai O, Gunzer M, Hasenberg M, Einsele H, Loeffler J (2014) Human dendritic cell subsets display distinct interactions with the pathogenic mould Aspergillus fumigatus
    Int J Med Microbiol 304(8):1160-8
  • Cunha C, Kurzai O, Löffler J, Aversa F, Romani L, Carvalho A (2014) Neutrophil Responses to Aspergillosis: New Roles for Old Players
    Mycopathologia 178(5-6):387-93
  • Jacobsen ID, Lüttich A, Kurzai O, Hube B, Brock M (2014) In vivo imaging of disseminated murine Candida albicans infection reveals unexpected host sites of fungal persistence during antifungal therapy
    J Antimicrob Chemother 69(10)9:2785-96
  • Das Gupta M, Fliesser M, Springer J, Breitschopf T, Schlossnagel H, Schmitt AL, Kurzai O, Hünniger K, Einsele H, Löffler J (2014) Aspergillus fumigatus induces microRNA-132 in human monocytes and dendritic cells
    Int J Med Microbiol 304(5-6):592-6
  • Quintin J, Voigt J, Voort RV, Jacobsen ID, Verschueren I, Hube B, Giamarellos-Bourboulis EJ, Meer JW, Joosten LA, Kurzai O, Netea MG (2014) Differential role of NK cells against Candida albicans infection in immunocompetent or immunocompromised mice
    Eur J Immunol 44(8):2405-14
  • Cunha C, Kurzai O, Carvalho A (2014) PTX3 deficiency and aspergillosis
    N Engl J Med 370(17):1666-7
  • Miramón P, Dunker C, Kasper L, Jacobsen ID, Barz D, Kurzai O, Hube B (2014) A family of glutathione peroxidases contributes to oxidative stress resistance in Candida albicans
    Med Mycol 52(3):223-39
  • Hünniger K, Lehnert T, Bieber K, Martin R, Figge MT, Kurzai O (2014) A virtual infection model quantifies innate effector mechanisms and Candida albicans immune escape in human blood
    PLoS Comput Biol 10(2):e1003479
  • Cunha C, Aversa F, Lacerda JF, Busca A, Kurzai O, Grube M, Löffler J, Maertens JA, Bell AS, Inforzato A, Barbati E, Almeida B, Santos e Sousa P, Barbui A, Potenza L, Caira M, Rodrigues F, Salvatori G, Pagano L, Luppi M, Mantovani A, Velardi A, Romani L, Carvalho A (2014) Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation
    N Engl J Med 30;370(5):421-32
  • Hentschel J, Müller U, Doht F, Fischer N, Böer K, Sonnemann J, Hipler C, Hünniger K, Kurzai O, Markert UR, Mainz JG (2014) Influences of nasal lavage collection-, processing- and storage methods on inflammatory markers - Evaluation of a method for non-invasive sampling of epithelial lining fluid in cystic fibrosis and other respiratory diseases
    J Immunol Methods 404:41-51
  • Voigt J, Hünniger K, Bouzani M, Jacobsen I, Barz D, Hube B, Löffler J, Kurzai O (2014) Phagocytosis of Candida albicans by human NK Cells results in a proinflammatory response
    J Inf Dis 209(4):616-26

2013

  • Hentschel J, Müller U, Doht F, Fischer N, Böer K, Sonnemann J, Hipler C, Hünniger K, Kurzai O, Markert UR, Mainz JG (2013) Influences of nasal lavage collection-, processing- and storage methods on inflammatory markers - Evaluation of a method for non-invasive sampling of epithelial lining fluid in cystic fibrosis and other respiratory diseases
    J Immunol Methods 404:41-51
  • Voigt J, Hünniger K, Bouzani M, Jacobsen I, Barz D, Hube B, Löffler J, Kurzai O (2013) Phagocytosis of Candida albicans by human NK Cells results in a proinflammatory response
    J Inf Dis 209(4):616-26
  • Luo S, Skerka C, Kurzai O, Zipfel P (2013) Complement and innate immune evasion strategies of the human pathogenic fungus Candida albicans
    Mol Immunol 56(3):161-169
  • Martin R, Albrecht-Eckardt D, Brunke S, Hube B, Hünniger K, Kurzai O (2013) A core filamentation response network in Candida albicans is restricted to eight genes
    PLoS One 8(3):e58613
  • Cottier F, Leewattanapasuk W, Kemp LR, Murphy M, Supuran CT, Kurzai O, Mühlschlegel FA (2013) Carbonic anhydrase regulation and CO(2) sensing in the fungal pathogen Candida glabrata involves a novel Rca1p ortholog
    Bioorg Med Chem 21(6):1549-54.

2012

  • Miramón P, Dunker C, Windecker H, Bohovych IM, Brown AJ, Kurzai O, Hube B (2012) Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress
    PLoS One 7(12): e52850
  • Escalante-Pérez M, Jaborsky M, Reinders J, Kurzai O, Hedrich R, Ache P (2012) Poplar extrafloral nectar is protected against plant and human pathogenic fungus.
    Mol Plant 5(5): 1157-9
  • Heddergott C, Bruns S, Nietzsche S, Leonhardt I, Kurzai O, Kniemeyer O, Brakhage AA (2012) The Arthroderma benhamiae hydrophobin HypA mediates hydrophobicity and influences recognition by human immune effector cells.
    Eukaryot Cell 11(5): 673-82
  • Cottier F, Raymond M, Kurzai O, Bolstad M, Leewattanapasuk W, Jiménez-López C, Lorenz MC, Sanglard D, Váchová L, Pavelka N, Palková Z, Mühlschlegel FA (2012) The bZIP Transcription Factor Rca1p Is a Central Regulator of a Novel CO(2) Sensing Pathway in Yeast.
    PLoS Pathog. 8(1): e1002485.
  • Bauer R, Mezger M, Blockhaus C, Schmitt AL, Kurzai O, Einsele H, Loeffler J (2011) 40-O -2-Hydroxyethylrapamycin modulates human dendritic cell function during exposure to Aspergillus fumigatus.
    J. Basic Microbiol. 52(3): 269-76

2011

  • Bouzani M, Ok M, McCormick A, Ebel F, Kurzai O, Morton CO, Einsele H, Loeffler J (2011) Human NK cells display important antifungal activity against Aspergillus fumigatus, which is directly mediated by IFN-? release.
    J. Immunol. 187(3): 1369-76
  • Kerstan A, Wendel AM, Kurzai O, Bröcker EB, Kolb-Mäurer A. (2011) Ulcerating nodules on the right arm after hunting muskrats.
    J. Dtsch. Dermatol. Ges. 9(6): 487-9
  • Martin R, Moran GP, Jacobsen ID, Heyken A, Domey J, Sullivan DJ, Kurzai O, Hube B (2011) The Candida albicans-Specific Gene EED1 Encodes a Key Regulator of Hyphal Extension.
    PLoS One 6(4): e18394.
  • Nägele V, Heesemann J, Schielke S, Jiménez-Soto LF, Kurzai O , Ackermann N. (2011) Neisseria meningitidis adhesin NadA targets {beta}1 integrins: Functional similarity to Yersinia invasin.
    J. Biol. Chem. 286(23): 20536-46
  • Morton CO, Clemons KV, Springer J, Mueller JG, Rogers TR, Stevens DA, Kurzai O , Einsele H, Loeffler J (2011) Real-time PCR and quantitative culture for monitoring of experimental Aspergillus fumigatus intracranial infection in neutropenic mice.
    J. Med. Microbiol. 60(Pt 7): 913-9
  • Kapp M, Schargus M, Deuchert T, Springer J, Wendel F, Loeffler J, Grigoleit GU, Kurzai O , Heinz W, Einsele H, Stuhler G (2011) Endophthalmitis as primary clinical manifestation of fatal fusariosis in an allogeneic stem cell recipient.
    Transpl. Infect. Dis. 13(4): 374-9
  • Schielke S, Spatz C, Schwarz RF, Joseph B, Schoen C, Schulz SM, Hubert K, Frosch M, Schubert-Unkmeir A, Kurzai O (2011) Characterization of FarR as a highly specialized, growth phase-dependent transcriptional regulator in Neisseria meningitidis.
    Int. J. Med. Microbiol. 301(4): 325-33
  • Morton CO, Varga JJ, Hornbach A, Mezger M, Sennefelder H, Kneitz S, Kurzai O , Krappmann S, Einsele H, Nierman WC, Rogers TR, Loeffler J (2011) The temporal dynamics of differential gene expression in Aspergillus fumigatus interacting with human immature dendritic cells in vitro.
    PLoS One 6(1): e16016.
  • Springer J, Loeffler J, Heinz W, Schloßnagel H, Lehmann M, Morton O, Rogers TR, Schmitt C, Frosch M, Einsele H, Kurzai O (2011) Pathogen-Specific DNA Enrichment Does Not Increase Sensitivity of PCR for Diagnosis of Invasive Aspergillosis in Neutropenic Patients.
    J. Clin. Microbiol. 49(4): 1267-1273

2010

  • Kurzai O (2010) Eradication is impossible.
    Dtsch. Arztebl. Int. 107(21): 369
  • Schielke S, Frosch M, Kurzai O (2010) Virulence determinants involved in differential host niche adaptation of Neisseria meningitidis and Neisseria gonorrhoeae.
    Med. Microbiol. Immunol. 199(3): 185-96
  • Schielke S, Schmitt C, Spatz C, Frosch M, Schubert-Unkmeir, Kurzai O (2010) The transcriptional repressor FarR is not involved in meningococcal fatty acid resistance mediated by the FarAB efflux pump and dependent on lipopolysaccharide structure.
    Appl. Environ. Microbiol. 76(10): 3160-9
  • Kleinert S, Kurzai O , Elias J, Marten K, Engelke C, Feuchtenberger M, Sandstede J, Frosch M, Tony HP, Kneitz C. (2010) Comparison of two interferon-gamma release assays and tuberculin skin test for detecting latent tuberculosis in patients with immune-mediated inflammatory diseases.
    Ann. Rheum. Dis. 69(4):782-4
  • Spinnler K, Mezger M, Steffens M, Sennefelder H, Kurzai O, Einsele H, Loeffler J. (2010) Role of glycogen synthase kinase 3 (GSK-3) in innate immune response of human immature dendritic cells to Aspergillus fumigatus.
    Med. Mycol. 48(4): 589-97

2009

  • Hornbach A, Heyken A, Schild L, Hube B, Loeffler J, Kurzai O (2009) The glycosylphosphatidylinositol-anchored protease Sap9 modulates the interaction of Candida albicans with human neutrophils.
    Infect. Immun. 77(12): 5216-24
  • Ok M, Latgé JP, Baeuerlein C, Ebel F, Mezger M, Topp M, Kurzai O, Killian D, Kapp M, Grigoleit GU, Sennefelder H, Arroyo J, Einsele H, Loeffler J (2009) Immune responses of human immature dendritic cells can be modulated by the recombinant Aspergillus fumigatus antigen Aspf1.
    Clin. Vaccine Immunol. 16(10): 1485-92
  • Schielke S, Huebner C, Spatz C, Nägele V, Ackermann N, Frosch M, Kurzai O, Schubert-Unkmeir A (2009) Expression of the meningococcal adhesin NadA is controlled by a transcriptional regulator of the MarR family.
    Mol. Microbiol. 72(4): 1054-67
  • Schmitt C, Villwock A, Kurzai O (2009) Recognition of meningococcal molecular patterns by innate immune receptors.
    Int. J. Med. Microbiol. 299(1): 9-20





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